Suppressor of TCR signaling-2 (STS-2) suppresses arthritis development in mice.

Namiko Okabe Koichiro OhmuraMasaki KatayamaShuji AkizukiNick CarpinoKosaku MurakamiRan NakashimaMotomu HashimotoYoshitaka ImuraHajime YoshifujiMasao TanakaTsuneyo Mimori

Published in: Modern rheumatology (2017)

We proved that STS-2 is involved in the arthritis development by collagen-induced arthritis. Higher IL-2 production from STS-2 KO T cells is suggested to have a main pathogenic role in arthritis development.

Keyphrases

rheumatoid arthritis
type diabetes
signaling pathway
regulatory t cells
immune response
adipose tissue
diabetic rats
dendritic cells
stress induced