Temporal Immune Profiling in the CSF and Blood of Patients with Aneurysmal Subarachnoid Hemorrhage.
Thomas A UjasKatie L AndersonJenny LutshumbaSamantha N HartJadwiga Turchan-CholewoKevin W HattonAdam D BachstetterBarbara S NikolajczykAnn M StowePublished in: medRxiv : the preprint server for health sciences (2024)
Our findings reveal a time-dependent immune response following aSAH, with distinct within-patient patterns in CSF and PB. The early CSF cytokine peak preceding immune cell changes suggests a potential mechanistic link and identifies the cytokine response as a promising therapeutic target. This cytokine surge may drive immune cell expansion and prime PBMCs for increased inflammatory activity, potentially contributing to DCI risk. Future studies should explore the importance and sources of specific cytokines in driving immune activation. These insights may inform the development of targeted immunomodulatory strategies for preventing or managing DCI in aSAH patients.
Keyphrases
- immune response
- end stage renal disease
- ejection fraction
- newly diagnosed
- genome wide
- chronic kidney disease
- peritoneal dialysis
- single cell
- prognostic factors
- heavy metals
- case report
- oxidative stress
- cerebrospinal fluid
- drinking water
- cancer therapy
- gene expression
- dna methylation
- inflammatory response
- drug delivery
- climate change
- case control