Outcomes of CEM43 in Predicting Thermal Damage Induced by Focal Laser Ablation in Controlled Ex Vivo Experiments: A Comparison to Histology and MRI.
K C C de BieR A A van KollenburgLuigi A M J G van RielM AlmasianJ E FreundP R BloemenR ZweijeJ CrezeeB F CoolenG J StrijkersT M de ReijkeJ R OddensA G J M van LeeuwenD M de BruinPublished in: Lasers in surgery and medicine (2024)
FLA on ex vivo human prostate showed no thermal damage on histopathology or MRI. Ex vivo porcine liver FLA resulted in identifiable ZID on histology and lesions on MRI. 240-CEM43 generally overestimated the ZID and had less variability compared to histology. Results from the Arrhenius model were in better agreement with the histology findings, but still did not predict the individual FLA-induced histological thermal damage. Inter-experiment ZID variability underlines the need for developing a more comprehensive predictive dosimetry model for FLA in PCa treatment.