Login / Signup

GLIS3 regulates transcription of thyroid hormone biosynthetic genes in coordination with other thyroid transcription factors.

Hong Soon KangSara A GrimmRaja JothiPilar SantistebanAnton M Jetten
Published in: Cell & bioscience (2023)
Our study indicates that GLIS3 regulates transcription of TH biosynthetic and TSH-inducible genes in thyroid follicular cells in coordination with PAX8, NKX2.1, and FOXE1 by binding within the same regulatory hub. GLIS3 does not cause major changes in chromatin structure at these common regulatory regions. GLIS3 may induce transcriptional activation by enhancing the interaction of these regulatory regions with other enhancers and/or RNA Polymerase II (Pol II) complexes.
Keyphrases
  • transcription factor
  • genome wide identification
  • dna binding
  • bioinformatics analysis
  • genome wide
  • induced apoptosis
  • gene expression
  • cell cycle arrest
  • dna methylation
  • dna damage
  • endoplasmic reticulum stress