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Sex differences in neural correlates of common psychopathological symptoms in early adolescence.

Francesca BiondoCharlotte Nymberg ThunellBing XuCongying ChuTianye JiaAlex IngErin Burke QuinlanNicole TayTobias BanaschewskiArun L W BokdeChristian BüchelSylvane DesrivièresHerta FlorVincent FrouinHugh GaravanPenny GowlandAndreas HeinzBernd IttermannJean-Luc MartinotHervé LemaitreFrauke NeesDimitri Papadopoulos OrfanosLuise PoustkaSabina MillenetJuliane H FröhnerMichael N SmolkaHenrik WalterRobert WhelanEdward D BarkerGunter Schumannnull null
Published in: Psychological medicine (2021)
Using a large, sex-balanced and community-based sample, our study lends support to the idea that externalizing symptoms of hyperactivity/inattention may be associated with different neural structures in male and female adolescents. The brain regions we report have been associated with a myriad of important cognitive functions, in particular, attention, cognitive and motor control, and timing, that are potentially relevant to understand the behavioural manifestations of hyperactive and inattentive symptoms. This study highlights the importance of considering sex in our efforts to uncover mechanisms underlying psychopathology during adolescence.
Keyphrases
  • depressive symptoms
  • young adults
  • sleep quality
  • mass spectrometry
  • high resolution
  • subarachnoid hemorrhage