Primary Sclerosing Cholangitis-Associated Cholangiocarcinoma Demonstrates High Intertumor and Intratumor Heterogeneity.

Annemarie C de VriesMaikel P PeppelenboschMichail DoukasJoanne VerheijCyriel Y PonsioenRonald van MarionMarco J BrunoBas Groot KoerkampWinand N M DinjensAnnemarie C de Vries

Published in: Clinical and translational gastroenterology (2021)

PSC-associated CCA is characterized by high intertumor and intratumor heterogeneity of both p53/p16 protein expression and genetic alterations in TP53/CDKN2A, indicating that these tumors consist of multiple subclones with substantially different genetic makeup. The high intertumor and intratumor heterogeneity in PSC-CCA should be acknowledged during the development of diagnostic and therapeutic strategies.

Keyphrases

single cell
genome wide
gene expression
dna methylation
ulcerative colitis