A bacterial negative transcription regulator binding on an inverted repeat in the promoter for epothilone biosynthesis.

Xin-Jing YueXiao-Wen CuiZheng ZhangRan PengPeng ZhangZhi-Feng LiYue-Zhong Li

Published in: Microbial cell factories (2017)

Esi binds to the epothilone promoter and down-regulates the transcriptional level of the whole gene cluster to affect the biosynthesis of epothilone. This is the first transcription regulator identified for epothilone biosynthesis.

Keyphrases

transcription factor
dna binding
genome wide identification
cell wall
gene expression
dna methylation
ms ms
genome wide
copy number