Soluble guanylyl cyclase stimulation and phosphodiesterase-5 inhibition improve portal hypertension and reduce liver fibrosis in bile duct-ligated rats.
Ksenia BrusilovskayaPhilipp KönigshoferDaniel LampachAdrian SzodlPaul SupperDavid BauerAndrea BeerJudith StiftGerald TimelthalerGeorg OberhuberBruno Karl PodesserMartha SeifKerstin ZinoberNataliya Rohr-UdilovaMichael TraunerThomas ReibergerPhilipp SchwablPublished in: United European gastroenterology journal (2020)
In a rodent model of biliary cirrhosis, the sGC stimulator RIO and the PDE-5 inhibitor TADA improved PHT. The decrease of sinusoidal vascular resistance was paralleled by a reduction in liver fibrosis and hepatic inflammation, while systemic haemodynamics were not affected.