Structural and biological insights into Klebsiella pneumoniae surface polysaccharide degradation by a bacteriophage K1 lyase: implications for clinical use.

I-Fan TuTzu-Lung LinFeng-Ling YangI-Ming LeeWei-Lin TuJiahn-Haur LiaoTzu-Ping KoWen-Jin WuJia-Tsrong JanMeng-Ru HoChing-Yi ChouAndrew H-J WangChung-Yi WuJin-Town WangKai-Fa HuangShih-Hsiung Wu

Published in: Journal of biomedical science (2022)

Our results provide insights into how the enzyme recognizes and depolymerizes the K1 CPS, and demonstrate the potential use of the protein not only as a therapeutic agent against K. pneumoniae, but also as a tool to prepare structurally-defined oligosaccharides for the generation of glycoconjugate vaccines against infections caused by this organism.

Keyphrases

klebsiella pneumoniae
multidrug resistant
escherichia coli
protein protein
amino acid
binding protein
risk assessment
respiratory tract