Peptidoglycan-Directed Chemical Ligation for Selective Inhibition on Gram-Positive Bacteria.
Feng JiangChengteng CaiLei GaoXinhui SuShoufa HanPublished in: ACS omega (2022)
Microbicides with distinct antibacterial mechanisms show potential to combat multi-drug resistance bacteria. We herein report peptidoglycan-directed chemical ligation (PGCL) between alkyne-bearing vancomycin and an azide-tagged cationic polymer. The former binds peptidoglycan and inhibits peptidoglycan crosslinking, while the latter interferes the integrity of the bacterial membrane. PGCL results in enhanced bactericidal activity against Gram-positive Staphylococcus aureus ( S. aureus ) over Gram-negative Escherichia coli ( E. coli ). These data indicate the potential of PGCL to selectively and synergistically inhibit Gram-positive pathogens via dual modality antibacterial mechanisms of peptidoglycan-inhibiting antibiotics and bacterial membrane-disrupting polycations.
Keyphrases
- gram negative
- multidrug resistant
- cell wall
- escherichia coli
- bacillus subtilis
- staphylococcus aureus
- human health
- methicillin resistant staphylococcus aureus
- signaling pathway
- silver nanoparticles
- biofilm formation
- big data
- risk assessment
- machine learning
- anti inflammatory
- cystic fibrosis
- essential oil
- deep learning