Risk Variants in or Near ZBTB40 AND NFATC1 Increase the Risk of Both IBD and Adverse Bone Health Outcomes Highlighting Common Genetic Underpinnings Across Both Diseases.

Kelly C CushingYanhua ChenXiaomeng DuVincent ChenAnnapurna KuppaPeter HigginsElizabeth K Speliotes

Published in: Inflammatory bowel diseases (2023)

Patients with IBD are at increased risk for low bone density, independent of steroid use. Variants in or near ZBTB40 and NFATC1 are associated with an increased risk of IBD and low bone density.

Keyphrases

bone mineral density
copy number
soft tissue
bone loss
bone regeneration
ulcerative colitis
postmenopausal women
genome wide
emergency department
body composition
dna methylation