Exploring a distinct FGFR2::DLG5 rearrangement in a low-grade neuroepithelial tumor: A case report and mini-review of protein fusions in brain tumors.
Paola Loreto PalacioXiaokang PanDan JonesJosé Javier OteroPublished in: Journal of neuropathology and experimental neurology (2024)
We report the novel clinical presentation of a primary brain neoplasm in a 30-year-old man with a mass-like area in the anteromedial temporal lobe. Histopathological analysis revealed a low-grade neuroepithelial tumor with cytologically abnormal neurons and atypical glial cells within the cerebral cortex. Molecular analysis showed a previously undescribed FGFR2::DLG5 rearrangement. We discuss the clinical significance and molecular implications of this fusion event, shedding light on its potential impact on tumor development and patient prognosis. Additionally, an extensive review places the finding in this case in the context of protein fusions in brain tumors in general and highlights their diverse manifestations, underlying molecular mechanisms, and therapeutic implications.
Keyphrases
- low grade
- high grade
- induced apoptosis
- spinal cord
- protein protein
- spinal cord injury
- subarachnoid hemorrhage
- functional connectivity
- cell cycle arrest
- cell proliferation
- resting state
- neuropathic pain
- signaling pathway
- endoplasmic reticulum stress
- single molecule
- cell death
- pi k akt
- anterior cruciate ligament reconstruction
- cerebral blood flow