Aggravation of pulmonary fibrosis after knocking down the aryl hydrocarbon receptor in the insulin-like growth factor 1 receptor pathway.

Sheng-Mao WuJaw-Ji TsaiHung-Chuan PanJack L ArbiserLeonardo Elia Meei-Ling Sheu

Published in: British journal of pharmacology (2022)

In the development of idiopathic pulmonary fibrosis, AhR and IGF1R play opposite roles via the TGF-β/Smad/STAT signalling cascade. The AhR/IGF1R axis is a potential target for the treatment of lung injury and fibrosis.

Keyphrases

idiopathic pulmonary fibrosis
pulmonary fibrosis
binding protein
transforming growth factor
growth hormone
interstitial lung disease
epithelial mesenchymal transition
pi k akt
cell proliferation
risk assessment