Physiologically based pharmacokinetic models for predicting lamotrigine exposure and dose optimization in pediatric patients receiving combination therapy with carbamazepine or valproic acid.
Zhiwei LiuWenxin ShaoXingwen WangKuo GengWenhui WangYiming LiYoujun ChenHaitang XiePublished in: Pharmacotherapy (2024)
We have successfully developed PBPK models and DDI models for LTG in adults and children, which provide a reference for rational drug use in the pediatric population.
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