Endothelial histone deacetylase 1 activity impairs kidney microvascular NO signaling in rats fed a high-salt diet.
Luke S DunawayAnthony K CookCailin E KellumClaudia EdellDavide BottaPatrick A MolinaRandee S SedakaLivius V d'UscioZvonimir S KatusicDavid M PollockEdward W InschoJennifer S PollockPublished in: Acta physiologica (Oxford, England) (2024)
We conclude that HS activates endothelial HDAC1 through PDEM leading to decreased NO signaling. This study provides novel insights into the molecular mechanisms by which a HS decreases renal microvascular endothelial NO signaling.