Methotrexate polyglutamate levels and co-distributions in childhood acute lymphoblastic leukemia maintenance therapy.

Jacob NerstingStine Nygaard NielsenKathrine GrellMaria PaerregaardJonas AbrahamssonBendik LundOlafur Gisli JonssonKaie PruunsildGoda VaitkevicieneJukka Kanerva Kjeld Schmiegelownull null

Published in: Cancer chemotherapy and pharmacology (2018)

Measuring erythrocyte MTXpg4 simplifies and can replace longer chain MTXpg monitoring. Resolving individual MTXpg identifies samples that are unsuitable for dose guidance due to high levels of MTXpg1 remaining in the plasma fraction because of recent MTX intake. All tested MTXpg subsets correlated with DNA-TG and may be used for ALL maintenance therapy dose adjustments, but the most informative subset remains to be identified.

Keyphrases

acute lymphoblastic leukemia
high dose
gene expression
genome wide
allogeneic hematopoietic stem cell transplantation
single molecule
peripheral blood
cell free
cell therapy
replacement therapy
early life
smoking cessation