Remote and Anesthetic-Induced Myocardial Preconditioning Is Preserved in Atherosclerotic LDL Receptor-/- Mice In Vivo.
Walter PetermichlKathrin EglmeierHenriette HesseMichael GruberBernhard GrafAndre BredthauerAndreas RedelPublished in: Cardiovascular therapeutics (2021)
We were able to demonstrate that a high-fat diet morphologically and functionally triggered atherosclerosis in LDLR-/- mice. Interestingly, LDLR-/- mice with an atherogenic diet had smaller infarct sizes compared to wild-type mice. Moreover, preconditioning additionally reduced myocardial infarct size in LDLR-/- mice. A long-term high-fat atherogenic diet and preconditioning seem to result in additive cardioprotection in LDLR-/- mice.
Keyphrases
- wild type
- high fat diet induced
- high fat diet
- insulin resistance
- acute myocardial infarction
- physical activity
- left ventricular
- adipose tissue
- cardiovascular disease
- ischemia reperfusion injury
- type diabetes
- weight loss
- metabolic syndrome
- skeletal muscle
- endothelial cells
- high glucose
- acute coronary syndrome
- blood brain barrier
- diabetic rats