Is stem cell transplantation still needed for adult Philadelphia chromosome-positive acute lymphoblastic leukemia receiving tyrosine kinase inhibitors therapy?: A systematic review and meta-analysis.
Ben PonvilawanSmith KungwankiattichaiNipith CharoenngamWeerapat OwattanapanichPublished in: PloS one (2021)
This systematic review and meta-analysis demonstrated superior results of HSCT in Ph+ ALL patients compared to CMT alone. Moreover, auto-HSCT could be implemented with comparable survival outcomes to allo-HSCT in patients with no available donor or when haploidentical HSCT is not feasible.
Keyphrases
- stem cell transplantation
- acute lymphoblastic leukemia
- hematopoietic stem cell
- high dose
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- bone marrow
- stem cells
- allogeneic hematopoietic stem cell transplantation
- copy number
- mesenchymal stem cells
- cord blood
- dna methylation
- cell therapy