Mucin 1 Inhibits Ferroptosis and Sensitizes Vitamin E to Alleviate Sepsis-Induced Acute Lung Injury through GSK3 β /Keap1-Nrf2-GPX4 Pathway.

Yu-Ming WangFang-Chen GongXing QiYan-Jun ZhengXiang-Tao ZhengYing ChenZhi-Tao Yangnull Qing-YeEn-Qiang MaoEr-Zhen Chen

Published in: Oxidative medicine and cellular longevity (2022)

Our study was the first to explore the changes of iron metabolism indicators in ALI/ARDS of sepsis, clarify the important role of ferroptosis in ALI/ARDS induced by sepsis, and reveal the effects and specific mechanisms of MUC1 in regulating ferroptosis, as well as the sensitization on vitamin E.

Keyphrases

cell death
septic shock
acute kidney injury
intensive care unit
acute respiratory distress syndrome
mechanical ventilation
extracorporeal membrane oxygenation
oxidative stress
lipopolysaccharide induced
diabetic rats
signaling pathway
high glucose
lps induced
gene expression
induced apoptosis
drug induced