Higher LDL-C/HDL-C Ratio Is Associated with Elevated HbA1c and Decreased eGFR Levels and Cardiac Remodeling in Elderly with Hypercholesterolemia.
Yufeng LiGang LiJari Antero LaukkanenLinping WeiXinrui ChenPublished in: Journal of cardiovascular development and disease (2024)
Background: This study aims to explore the relationship of the low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein (HDL-C) ratio with glycated hemoglobin (HbA1c), renal dysfunction, coronary heart disease (CHD) and cardiac structure and function in elderly patients with hypercholesterolemia. Methods : A total of 1129 hospitalized Chinese elderly (aged ≥ 65 years) with hypercholesterolemia were collected retrospectively. The patients were divided into low (<2.63), moderate (≥2.63 to <3.33) and high (≥3.33) LDL-C/HDL-C ratio groups according to the tertiles of LDL-C/HDL-C. Results : Regression analysis of the LDL-C/HDL-C ratio with metabolic and echocardiographic parameters revealed that a high LDL-C/HDL-C ratio (≥3.33) was associated independently with male gender, elevated HbA1c, decreased estimated glomerular filtration rate (eGFR), prevalent CHD and left ventricular dilatation (all p < 0.05). Conclusions : A high LDL-C/HDL-C ratio was associated with male gender, increased HbA1c, decreased eGFR, CHD and enlarged left ventricle in elderly with hypercholesterolemia.
Keyphrases
- low density lipoprotein
- left ventricular
- small cell lung cancer
- epidermal growth factor receptor
- middle aged
- high density
- tyrosine kinase
- community dwelling
- heart failure
- ejection fraction
- pulmonary hypertension
- type diabetes
- acute myocardial infarction
- end stage renal disease
- oxidative stress
- pulmonary artery
- hypertrophic cardiomyopathy
- single cell
- left atrial
- pulmonary arterial hypertension
- coronary artery
- acute coronary syndrome
- congenital heart disease
- aortic valve
- cardiac resynchronization therapy
- peritoneal dialysis