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Chemiluminescent organic nanophotosensitizer for a penetration depth independent photodynamic therapy.

Xiaomei LuXingwen SongQi WangWenbo HuWei ShiYufu TangZizi WuQu-Li FanWei Huang
Published in: RSC advances (2020)
Photodynamic therapy initiated by external photoexcitation is a clinically-approved therapeutic paradigm, but its practical application has been severely hindered by the shallow penetration of light. Here, we describe a penetration-independent PDT modality using a chemiluminescent organic nanophotosensitizer, which is activated by hydrogen peroxide instead of external photoexcitation.
Keyphrases
  • photodynamic therapy
  • hydrogen peroxide
  • fluorescence imaging
  • nitric oxide
  • water soluble
  • optical coherence tomography