Associations between maternal plasma zinc concentrations in late pregnancy and LINE-1 and Alu methylation loci in the young adult offspring.
Amaraporn RerkasemSothida NantakoolBrooke C WilsonAmpica MangklabruksKongsak BoonyapranaiApiwat MutiranguraJosé G B DerraikKitttipan RerkasemPublished in: PloS one (2022)
Lower maternal zinc concentrations late in gestation were associated with changes in DNA methylation in later life. Thus, zinc deficiency during pregnancy may induce alterations in total LINE-1 methylation and LINE-1 hypermethylation loci. These results suggest a possible epigenetic link between zinc deficiency during pregnancy and long-term outcomes in the offspring.
Keyphrases
- dna methylation
- genome wide
- oxide nanoparticles
- pregnancy outcomes
- gene expression
- high fat diet
- birth weight
- preterm infants
- genome wide association study
- copy number
- type diabetes
- replacement therapy
- metabolic syndrome
- pregnant women
- genome wide association
- insulin resistance
- weight loss
- weight gain
- smoking cessation