Alpha-Ketoglutarate Attenuates Colitis in Mice by Increasing Lactobacillus Abundance and Regulating Stem Cell Proliferation via Wnt-Hippo Signaling.
Xuemeng SiHai JiaNing LiuJun LiLina PanJiaqi WangZhenlong WuPublished in: Molecular nutrition & food research (2022)
Collectively, the data provided herein demonstrate that α-KG administration is attenuated mucosal inflammation, barrier dysfunction, and gut microflora dysbiosis. This beneficial effect is associated with increased Lactobacillus levels and regulated colon hyperplasia by the Wnt-Hippo signaling pathway.
Keyphrases
- cell proliferation
- pi k akt
- signaling pathway
- oxidative stress
- cell cycle
- ulcerative colitis
- stem cells
- transcription factor
- electronic health record
- high fat diet induced
- epithelial mesenchymal transition
- induced apoptosis
- machine learning
- type diabetes
- adipose tissue
- data analysis
- wastewater treatment
- endoplasmic reticulum stress