Comprehensive Analysis of Metabolic Isozyme Targets in Cancer.
Michał MarczykVignesh GunasekharanDavid CasadevallTao QingJulia FoldiRaghav SehgalNaing Lin ShanKim R M BlenmanTess A O'MearaSheila UmlaufYulia V SurovtsevaViswanathan MuthusamyJesse RinehartRachel J PerryRichard KibbeyChristos HatzisLajos PusztaiPublished in: Cancer research (2022)
This study exploits the loss of metabolic isozyme diversity common in cancer and reveals a rich pool of potential therapeutic targets that will allow the repurposing of existing inhibitors for anticancer therapy. See related commentary by Kehinde and Parker, p. 1695.