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The Complex Interplay between Immunonutrition, Mast Cells, and Histamine Signaling in COVID-19.

Sotirios KakavasDimitrios KarayiannisZafeiria Mastora
Published in: Nutrients (2021)
There is an ongoing need for new therapeutic modalities against SARS-CoV-2 infection. Mast cell histamine has been implicated in the pathophysiology of COVID-19 as a regulator of proinflammatory, fibrotic, and thrombogenic processes. Consequently, mast cell histamine and its receptors represent promising pharmacological targets. At the same time, nutritional modulation of immune system function has been proposed and is being investigated for the prevention of COVID-19 or as an adjunctive strategy combined with conventional therapy. Several studies indicate that several immunonutrients can regulate mast cell activity to reduce the de novo synthesis and/or release of histamine and other mediators that are considered to mediate, at least in part, the complex pathophysiology present in COVID-19. This review summarizes the effects on mast cell histamine of common immunonutrients that have been investigated for use in COVID-19.
Keyphrases
  • coronavirus disease
  • sars cov
  • respiratory syndrome coronavirus
  • systemic sclerosis
  • idiopathic pulmonary fibrosis
  • transcription factor
  • atomic force microscopy
  • bone marrow
  • high resolution
  • high speed
  • single molecule