Severe COVID-19 is associated with molecular signatures of aging in the human brain.
Maria MavrikakiJonathan D LeeIsaac H SolomonFrank J SlackPublished in: Nature aging (2022)
As coronavirus disease 2019 (COVID-19) and aging are both accompanied by cognitive decline, we hypothesized that COVID-19 might lead to molecular signatures similar to aging. We performed whole-transcriptome analysis of the frontal cortex, a critical area for cognitive function, in individuals with COVID-19, age-matched and sex-matched uninfected controls, and uninfected individuals with intensive care unit/ventilator treatment. Our findings indicate that COVID-19 is associated with molecular signatures of brain aging and emphasize the value of neurological follow-up in recovered individuals.
Keyphrases
- coronavirus disease
- sars cov
- cognitive decline
- intensive care unit
- respiratory syndrome coronavirus
- genome wide
- hiv infected
- mild cognitive impairment
- functional connectivity
- mechanical ventilation
- gene expression
- single molecule
- resting state
- working memory
- white matter
- multiple sclerosis
- early onset
- rna seq
- single cell
- brain injury