Dual effects of dulaglutide on glycemic control and knee osteoarthritis pain in elderly patients with Type 2 diabetes.
Shambo Samrat SamajdarGaurab BhaduriPradip Kumar GhoshalShatavisa MukherjeeJyotirmoy PalNandini ChatterjeeShashank R JoshiPublished in: Pain management (2024)
Aim: This study aims to evaluate the dual benefits of dulaglutide in improving glycemic control and reducing knee OA pain. Patients & methods: Elderly T2DM patients diagnosed with bilateral knee OA on conventional OA treatment for at least 3 months were studied for their glycemic metrics, OA pain scores and NSAID consumption at baseline, 3 months and 6 months. Results: Significant improvements in glycemic control were observed, HbA1c decreased from 8.7% to 6.5% over 6 months. Pain scores, NSAID, body weight and BMI showed substantial reductions over time. Positive correlation (r = 0.73, p < 0.001) was found between glycemic control and pain reduction. Conclusion: Dulaglutide improves glycemic control, knee joint OA pain and weight management in elderly patients with T2DM.
Keyphrases
- glycemic control
- knee osteoarthritis
- type diabetes
- chronic pain
- blood glucose
- weight loss
- pain management
- neuropathic pain
- insulin resistance
- end stage renal disease
- body weight
- newly diagnosed
- total knee arthroplasty
- body mass index
- prognostic factors
- middle aged
- peritoneal dialysis
- patient reported outcomes
- weight gain
- combination therapy
- spinal cord injury