Synthesis, Molecular Docking Screening and Anti-Proliferative Potency Evaluation of Some New Imidazo[2,1-b]Thiazole Linked Thiadiazole Conjugates.
Huda R M RashdanAboubakr Haredi AbdelmonsefIhsan A ShehadiSobhi Mohamed GomhaAbdel Mohsen M SolimanHuda K MahmoudPublished in: Molecules (Basel, Switzerland) (2020)
All the tested compounds had exhibited good anti-proliferative efficacy against hepatic cancer cell lines. In addition, the molecular docking results showed strong binding interactions of the synthesized compounds with the target GPC-3 protein with lower energy scores. Thus, such novel compounds may act as promising candidates as drugs against hepatocellular carcinoma.