High sucrose low copper diet in pregnant diabetic rats induces transient oxidative stress, hypoxia, and apoptosis in the offspring's liver.
Zivanit ErgazLiza Weinstein-FudimAsher OrnoyPublished in: Birth defects research (2018)
The changes in the Sabra rats HSD were attributed to the pro-oxidant effects of the diet and those in the diabetic CDs to the HSD and maternal diabetes. In light of the DNA methylation changes in the liver of the CDs HSD, we presume that changes in gene expression are responsible for our findings, and that similar changes may lead to the metabolic syndrome at adulthood.
Keyphrases
- diabetic rats
- oxidative stress
- dna methylation
- gene expression
- quantum dots
- metabolic syndrome
- type diabetes
- weight loss
- physical activity
- ischemia reperfusion injury
- dna damage
- induced apoptosis
- anti inflammatory
- cardiovascular disease
- genome wide
- pregnant women
- high fat diet
- depressive symptoms
- visible light
- cell death
- pregnancy outcomes
- cardiovascular risk factors
- uric acid
- birth weight
- endoplasmic reticulum stress
- early life
- skeletal muscle
- copy number
- heat shock
- weight gain
- signaling pathway
- adipose tissue
- heat stress
- gestational age