Breast cancer screening implications of risk modeling among female relatives of ATM and CHEK2 carriers.
Anne E WeidnerMariel E LigginBrenda I ZunigaAnn L TezakGeorgia L WiesnerTuya PalPublished in: Cancer (2020)
The results of the current study suggest that the majority of female first-degree and second-degree relatives of ATM and CHEK2 carriers do not qualify for breast MRI based on family cancer history alone. Therefore, testing for these genes, as well as awareness of positive moderate-penetrance breast cancer gene results in the family, may impact MRI eligibility. These findings highlight the potential usefulness of and need for breast cancer risk models that incorporate moderate-penetrance gene positivity to inform screening recommendations among at-risk family members.
Keyphrases
- breast cancer risk
- genome wide
- genome wide identification
- contrast enhanced
- dna damage
- magnetic resonance imaging
- copy number
- high intensity
- dna repair
- dna damage response
- papillary thyroid
- genome wide analysis
- diffusion weighted imaging
- dna methylation
- squamous cell
- childhood cancer
- gene expression
- oxidative stress
- magnetic resonance
- climate change
- human health