A hypolipoprotein sepsis phenotype indicates reduced lipoprotein antioxidant capacity, increased endothelial dysfunction and organ failure, and worse clinical outcomes.

Faheem W GuirgisLauren Page BlackMorgan HensonGuillaume LabilloyCarmen SmothermanCharlotte HopsonIan TfirnElizabeth L DeVosChristiaan LeeuwenburghLyle MoldawerSusmita DattaTodd M BruskoAlexis HesterAndrew BertrandVictor GrijalvaAlexander Arango-EsterhayFrederick A MooreSrinivasa T Reddy

Published in: Critical care (London, England) (2021)

Lipoproteins predicted poor sepsis outcomes. A Hypolipoprotein sepsis phenotype was identified and characterized by lower lipoprotein levels, increased endothelial dysfunction (ICAM-1) and organ failure, and worse clinical outcomes.

Keyphrases

septic shock
acute kidney injury
intensive care unit
type diabetes
adipose tissue
metabolic syndrome