Altered ethanol metabolism and increased oxidative stress enhance alcohol-associated liver injury in farnesoid X receptor-deficient mice.

Caroline MorelVivek ChowdharyPrashanth Thevkar NageshMarcelle RibeiroDanielle HawrylukDonna CatalanoLuciano AdoriniGyongyi Szabo

Published in: Liver international : official journal of the International Association for the Study of the Liver (2022)

ALD pathogenesis in FXR KO mice correlates with altered ethanol metabolism and increased oxidative stress, providing new insights into the protective function of FXR in ALD.

Keyphrases

liver injury
oxidative stress
drug induced
dna damage
ischemia reperfusion injury
diabetic rats
induced apoptosis
alcohol consumption
signaling pathway
endoplasmic reticulum stress
heat stress