Seed becoming soil: A new paradigm of the Ewing sarcoma tumor microenvironment.

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

Cells in the tumor tumor microenvironment, including cancer-associated fibroblasts (CAFs), contribute to tumor growth and immune evasion. A recent study of Ewing sarcoma identified "CAF-like" tumor cells that mimic the pro-tumorigenic features of CAFs. These findings highlight the role of cell plasticity in tumor growth.

Keyphrases

induced apoptosis
cell cycle arrest
single cell
cell therapy
stem cells
cell death
mesenchymal stem cells
bone marrow