Chlamydia trachomatis induces low-frequency, sustained CD4 T cell responses in most women, predominantly targeting chlamydial protease-like activity factor, CPAF.
Yanli LiJoanna A WarrenTaylor B PostonGenevieve T CluttonFiona R ShawShayla Z ConradYinyan XuXiaojing ZhengKacy S YountCatherine M O'ConnellHarold C WiesenfeldToni DarvilleNilu GoonetillekePublished in: The Journal of infectious diseases (2024)
Our results indicate that CT infection elicits low-frequency, persistent CD4 T cell responses in most women and that the secreted protein, CPAF, is an immunoprevalent CT antigen. Altogether, these data support development and testing of CT vaccines that enhance CD4 T cells against CPAF.
Keyphrases
- image quality
- dual energy
- computed tomography
- contrast enhanced
- polycystic ovary syndrome
- positron emission tomography
- pregnancy outcomes
- magnetic resonance imaging
- electronic health record
- cervical cancer screening
- type diabetes
- drug delivery
- big data
- protein protein
- machine learning
- small molecule
- amino acid
- african american
- pet ct