Interleukin-1β induces apoptosis in annulus fibrosus cells through the extracellular signal-regulated kinase pathway.

Xing YangLei WangZhang-Qin YuanPing-Hui ZhouGeng-Lei ChuBin Li Jun-Ying Sun

Published in: Connective tissue research (2018)

Findings from this study suggest that IL-1β induces apoptosis in AFCs through the ERK pathway, and therefore, ERK inhibition may provide certain protection against the adverse effects of IL-1β.

Keyphrases

signaling pathway
induced apoptosis
pi k akt
cell proliferation
cell cycle arrest
aortic valve
transcription factor
emergency department
endoplasmic reticulum stress
tyrosine kinase