Increased 14C-acetate accumulation in IDH-mutated human glioblastoma: implications for detecting IDH-mutated glioblastoma with 11C-acetate PET imaging.

Sho KoyasuYoichi ShimizuAkiyo MorinibuTsuneo SagaYuji NakamotoKaori TogashiHiroshi Harada

Published in: Journal of neuro-oncology (2019)

In vitro and in vivo studies demonstrated that the uptake of radiolabeled acetate was significantly higher in IDH-mutated cells than in IDH-wild-type cells.

Keyphrases

wild type
induced apoptosis
pet imaging
cell cycle arrest
low grade
endothelial cells
endoplasmic reticulum stress
oxidative stress
computed tomography
positron emission tomography
induced pluripotent stem cells
cell proliferation
pi k akt
case control