Pulmonary surfactant impacts in vitro activity of selected antifungal drugs against Candida krusei and Candida albicans.

Markus ZeitlingerPeter MatznellerSabine EberlMarkus Zeitlinger

Published in: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (2024)

This in-vitro study highlights the concentration-dependent inhibitory effect of surfactant on antifungal activity against C. krusei and, to some extent, C. albicans, necessitating further clinical validation for invasive lung mycoses treatment.

Keyphrases

candida albicans
biofilm formation
pulmonary hypertension
cystic fibrosis
staphylococcus aureus
drug induced