Multiple sclerosis risk variants influence the peripheral B-cell compartment early in life in the general population.

Casper L de MolMarvin M van LuijnKarim L KreftKirsten I M LoomanMenno C van ZelmTonya WhiteHenriette A MollJoost J F M SmoldersRinze F Neuteboom

Published in: European journal of neurology (2022)

The composition of the blood B-cell compartment is associated with specific naive B-cell-associated MS risk variants during childhood, possibly contributing to MS pathophysiology later in life. Cell subset-specific PRSs may offer a more sensitive tool to define the impact of genetic risk on the immune system in diseases such as MS.

Keyphrases

multiple sclerosis
mass spectrometry
ms ms
copy number
single cell
gene expression
cell therapy
mesenchymal stem cells
bone marrow
childhood cancer