Preclinical and first-in-human-brain-cancer applications of [18F]poly (ADP-ribose) polymerase inhibitor PET/MR.
Robert J YoungPaula Demétrio De Souza FrançaGiacomo PirovanoAnna F PiotrowskiPhilip J NicklinChristopher C RiedlJazmin SchwartzTejus A BalePatrick L DonabedianSusanne KossatzEva M BurnaziSheryl RobertsSerge K LyashchenkoAlexandra M MillerNelson S MossMegan FiasconaroZhigang ZhangAudrey MauguenThomas ReinerMark P DunphyPublished in: Neuro-oncology advances (2020)
Although larger studies are necessary to confirm and further explore this tracer, we describe the promising performance of [18F]PARPi as a diagnostic tool to evaluate patients with brain cancers and possible treatment-related changes.