PDZ-Binding Kinase, a Novel Regulator of Vascular Remodeling in Pulmonary Arterial Hypertension.
Zsuzsanna BordanRobert K BatoriStephen HaighXueyi LiMary Louise MeadowsZachary L BrownMadison A WestKunzhe DongWeihong HanYunchao SuQian MaYuqing HuoJiliang ZhouMahmoud AbdelbaryJennifer C SullivanNeal L WeintraubDavid W SteppFeng ChenScott A BarmanDavid J R FultonPublished in: Circulation (2024)
PBK is a newly described target for PAH that is upregulated in proliferating PA smooth muscle cells, where it contributes to proliferation through changes in cytokinesis and cell cycle dynamics to promote medial thickening, fibrosis, increased PA resistance, elevated right ventricular systolic pressure, right ventricular remodeling, and PH.
Keyphrases
- cell cycle
- pulmonary arterial hypertension
- pulmonary artery
- cell proliferation
- pulmonary hypertension
- blood pressure
- heart failure
- left ventricular
- signaling pathway
- transcription factor
- protein kinase
- tyrosine kinase
- polycyclic aromatic hydrocarbons
- dna binding
- coronary artery
- binding protein
- atrial fibrillation
- liver fibrosis