BRAF Targeting Sensitizes Resistant Melanoma to Cytotoxic T Cells.

Cigdem AtayTaekyoung KwakSergio Lavilla-AlonsoLaxminarasimha DonthireddyAllison RichardsValerie MobergShari Pilon-ThomasMichael SchellJane L MessinaVito W RebeccaMin XiaoJiufeng TanGao ZhangJeffrey S WeberMeenhard HerlynAmod A SarnaikDmitry I Gabrilovich

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

BRAF-targeted therapy sensitized resistant melanoma cells to CTLs, which opens new therapeutic opportunities for the treatment of patients with BRAF-resistant disease.See related commentary by Goff and Rosenberg, p. 2682.

Keyphrases

metastatic colorectal cancer
wild type
oxidative stress
induced apoptosis
drug delivery
combination therapy
signaling pathway
endoplasmic reticulum stress
skin cancer
smoking cessation