Bias from depletion of susceptibles: the example of hormone replacement therapy and the risk of venous thromboembolism.

Christel RenouxSophie Dell'AnielloBenjamin BrennerSamy Suissa

Published in: Pharmacoepidemiology and drug safety (2017)

The phenomenon of depletion of susceptibles should be considered in cohort studies evaluating acute side effects of medications. This can be achieved by estimating the risk as a function not only of current use but also of duration of use. Copyright © 2017 John Wiley & Sons, Ltd.

Keyphrases

replacement therapy
venous thromboembolism
smoking cessation
liver failure
direct oral anticoagulants
respiratory failure
aortic dissection
drug induced
atrial fibrillation
acute respiratory distress syndrome
mechanical ventilation