Epigenetic reactivation of tumor suppressor genes with CRISPRa technologies as precision therapy for hepatocellular carcinoma.
Agustin SgroJoseph CursonsCharlene WaryahEleanor A WoodwardMomeneh ForoutanRuqian LyuGeorge C T YeohPeter J LeedmanPilar BlancafortPublished in: Clinical epigenetics (2023)
By combining multiple effector domains, we demonstrate the utility of a CRISPRa toolbox of epigenetic effectors and gRNAs for patient-specific treatment of aggressive HCC.