Platelet mitochondrial DNA methylation predicts future cardiovascular outcome in adults with overweight and obesity.

Sarah CorsiSimona IodiceLuisella VignaAkin CayirJohn C MathersValentina BollatiHyang-Min Byun

Published in: Clinical epigenetics (2020)

Methylations of MT-CO1, MT-CO3, and MT-TL1 are, together, strong predictors of future CVD incidence. Since methylation of these mtDNA domains was independent of conventional CVD risk factors, these markers may represent a novel intrinsic predictor of CVD risk in adults with overweight and obesity.

Keyphrases

risk factors
dna methylation
current status
genome wide
copy number
gene expression
oxidative stress
mitochondrial dna