Leptin bioavailability and markers of brain atrophy and vascular injury in the middle age.

Sokratis CharisisMeghan I ShortRebecca BernalTiffany F KautzHector A TreviñoJulia MathewsAngel Gabriel Velarde DediósJazmyn A S MuhammadAlison M LuckeyAsra AslamJayandra J HimaliEric L ShippMohamad HabesAlexa S BeiserCharles DeCarliNikolaos ScarmeasVasan S RamachandranSudha SeshadriPauline MaillardClaudia L Satizabal

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

Higher leptin bioavailability was related to better preservation of white matter microstructure. Higher leptin bioavailability during midlife might confer protection against dementia. Potential benefits might be even stronger for individuals with visceral obesity. DTI measures might be sensitive surrogate markers of subclinical neuropathology.

Keyphrases

white matter
multiple sclerosis
insulin resistance
metabolic syndrome
type diabetes
weight loss
mild cognitive impairment
weight gain
high fat diet induced
cognitive impairment
adipose tissue
body mass index
risk assessment
skeletal muscle
physical activity
resting state
climate change