Trans-Synaptic Degeneration in the Visual Pathway in Patients With Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.
Luca BolloGeorgina ArrambideÁlvaro Cobo-CalvoJavier V AlvarezManel AlberichSergio CabelloJoaquín CastillóIngrid GalanLuciana S MidagliaBreogan Rodriguez AcevedoAnna ZabalzaAgustín PappollaNeus Mongay OchoaMar TintoreJordi RíoManuel ComabellaCarmen TurCristina AugerJaume Sastre-GarrigaÀlex RoviraXavier MontalbanDeborah ParetoÁngela Vidal-JordanaPublished in: Neurology (2024)
Compared with HC, MOGAD-ON exhibits reduced retinal thickness, primarily influenced by the presence and the number of prior ON episodes. Moreover, MOGAD-ON demonstrates significant atrophy in the retinal, subcortical, and cortical regions of the visual pathway, distinguishing them from MOGAD-NON and HC. These findings suggest that in patients with MOGAD neurodegeneration is tightly correlated with damage to the involved pathway.