Advanced glycation endproducts induce self- and cross-tolerance in monocytes.

Florian UhleSebastian WeitererBenedikt Hermann SieglerThorsten BrennerChristoph LichtensternMarkus Alexander Weigand

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2017)

High levels of AGEs are capable to activate immune cells at first, but induce a secondary state of hypo-responsiveness in these cells. Based on the origin of its causal agent, we propose this phenomenon to be "metabolic tolerance".

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
dendritic cells
signaling pathway
peripheral blood
immune response
pi k akt