The small molecule CBR-5884 inhibits the Candida albicans phosphatidylserine synthase.

Yue ZhouGregory A PhelpsMikayla M MangrumJemma McLeishElise K PhillipsJinchao LouChristelle F AncajasJeffrey M RybakPeter M OelkersRichard E LeeMichael D BestTodd B Reynolds

Published in: mBio (2024)

value of 1,550 ± 245.6 nM and, thus, has the potential for development into a new class of antifungals targeting PS synthase.

Keyphrases

candida albicans
small molecule
biofilm formation
protein protein
photodynamic therapy
cancer therapy
human health
escherichia coli
drug delivery