Urine Galectin-3 binding protein reflects nephritis activity in systemic lupus erythematosus.

Francesca Faustini Helena IdborgEnrico FuzziAnders LarssonWen-Rong LieSven PötzschShinji L OkitsuElisabet SvenungssonIva Gunnarsson

Published in: Lupus (2022)

Given its ability to discriminate LN patients from active non-renal and inactive SLE patients, the observed correlation with the activity index in renal biopsies, and its levels declining following treatment, u-Gal-3BP shows promise as a non-invasive urinary biomarker to help detecting and to monitor renal involvement in SLE patients and should be validated in larger cohorts.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
systemic lupus erythematosus
prognostic factors
binding protein
machine learning
patient reported outcomes