Integrated transcriptomic and metabolomic analysis reveals the underlying mechanisms for male reproductive toxicity of polystyrene nanoplastics in mouse spermatocyte-derived GC-2spd(ts) cells.

Hang HanZhen ZhangBo XuLiyang DingHong YangTiantian HeXing DuXiuying PeiXufeng Fu

Published in: Toxicology in vitro : an international journal published in association with BIBRA (2024)

Our integrated approach, combining metabolomics and transcriptomics profiles with phenotype data, enhances our understanding of the adverse effects of PS-NPs on germ cells.

Keyphrases

induced apoptosis
cell cycle arrest
single cell
mass spectrometry
endoplasmic reticulum stress
emergency department
electronic health record
signaling pathway
big data
cell proliferation
machine learning
data analysis
gas chromatography